On the advice of Matisse and Jeanne Bucher, Dina Vierny, Maillol's last model, decided to open a gallery in 1947. She moved into 36 rue Jacob, a former "bougnat" converted into a wooden showcase by Auguste Perret.

The gallery became famous in Paris thanks to a first Maillol exhibition, and then established itself with exhibitions of works by Rodin, Henri Laurens, Matisse, etc. Dina Vierny met Serge Poliakoff and organised his first major exhibition in 1951. This was followed by exhibitions in the Vollard suite of Picasso, Kandinsky, Pougny, Dufy, Doucet, Charchoune, Gilioli, Couturier and Zitman. The gallery owner then turned her attention to the modern Primitives, exhibiting works by Bauchant, Bombois, Ève, Desnos, Racoff, Rimbert, Séraphine de Senlis and Vivin. In the early 1970s, she travelled to the Soviet Union, where she discovered Kabakov, Boulatov, Yankilevsky and Oscar Rabin. She smuggled their work out of Russia and organised the famous exhibition Russian Avant-Garde - Moscow 73.

Still driven by the same eclecticism, the gallery was then run by Olivier Lorquin, son of Dina Vierny, who left́ his place to his two sons, Pierre and Alexandre Lorquin, in January 2021. They are now redirecting the gallery's strategy towards modern and post-war art, diversifying the list of artists exhibited and organising ambitious exhibitions always accompanied by publications.

Since 2021, the gallery has presented́ exhibitions dedicated to Maillol (Maillol, la forme libre; Maillol Héritage; Maillol sensuel), Séraphine, Judit Reigl (Judit Reigl: première abstraction; Judit Reigl, Panta Rhei), Robert Couturier and Germaine Richier (Couturier - Richier : A sculptural friendship), Ra'anan Levy (Ra'anan Levy - Engraving; Tribute to Ra'anan Levy), Émile Gilioli, Michel Haas, the Modern Primitives (Bleu-Rouge-Jaune, the palette of the Modern Primitives) or even Russian non-conformist artists. Since 2022, Galerie Dina Vierny has been delighted to be making its return to international art fairs, taking part in BRAFA, Art Paris, the Salon du Dessin and FAB.