On the advice of Matisse and Jeanne Bucher, Dina Vierny, the last model of Maillol, decided to open a gallery in 1947. She settled at 36 Rue Jacob, a former wine merchant transformed into a wooden showcase by Auguste Perret.

The gallery gained prominence in Paris with its first Maillol exhibition and continued to assert itself with shows featuring Rodin, Henri Laurens, Matisse, and others. Dina Vierny met Serge Poliakoff and organized his first significant exhibition in 1951. Subsequent exhibitions featured Picasso's Vollard Suite, Kandinsky, Pougny, Dufy, Doucet, Charchoune, Gilioli, Couturier, and Zitman. The gallerist then developed an interest in Modern Primitives, exhibiting works by Bauchant, Bombois, Ève, Desnos, Racoff, Rimbert, Séraphine de Senlis, and Vivin. In the early '70s, she traveled to the Soviet Union, discovering Kabakov, Boulatov, Yankilevsky, and Oscar Rabin. She clandestinely brought their works out of Russia and organized the famous exhibition Russian Avant-garde – Moscow 73.

Driven by the same eclecticism, the gallery was later directed by Olivier Lorquin, Dina Vierny's son, who passed the reins to his two sons, Pierre and Alexandre Lorquin, in January 2021. They have since redirected the gallery's strategy towards Impressionism, modern and post-war art, diversifying the list of artists.